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White Matter Signal Abnormalities in Normal Individuals:Correlation with Cerebrovascular Risk Factors
Stroke 19:1285-1288, Fazekas,F.,et al, 1988
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Article Abstract
We studied 52 asymptomatic subjects using magnetic resonance imaging,and we compared age-matched groups(51-70 years old)with and without white matter lesions with respect to carotid ultrasonography,cerebral blood flow (xenon-133 injection),and cerebrovascular risk factors.In the group with white matter signal abnormalities,we noted a higher frequency of extracranial carotid artery disease,a lower mean gray matter blood flow (F1),and a significant reduction(p<0.05)in blood flow of the slow-flowing (F2)compartment.Hypertension,diabetes mellitus,and cardiac diseases(p<0. 002)were found more often in this group.Our results indicate that a higher incidence of changes known to be associated with an increased risk for stroke exists in the presence of white matter lesions in normal elderly individuals.
 
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cerebrovascular disease,risk factors in
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white matter disease

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